By making appropriate decision
Whether Pain Suppression is on cool down or not should be checked before spamming your raid talk, then aiming the spell to your target. Discipline priests are able to employ a similar version of this macro for Power Infusion, some with timers and other cool extras. In-combat buffing is favorite macro in combat for some players. Being a priest, getting Fortitude back on a player that has been revived in battle is a top priority, especially when that player is a tank. You can save a lot of Granado Espada vis by making appropriate decision.